Dr. Krishna Mohan Poluri - Department of Biosciences and Bioengineering,Indian Institute of Technology Roorkee
Dr. Krishna Mohan Poluri
Krishna Mohan Poluri Associate professor krishna.poluri@bt.iitr.ac.in +91-1332-284779
Areas of Interest
  • Biomolecular NMR Spectroscopy, Molecular Biophysics, Structural Biology, Biophysical Chemistry, Protein Evolution-Structure-Stability-Dynamics-Function Paradigm, Biomolecular Interactions, Structure based Drug Design, Structural Immunology, Glycobiology, Structural Virology, Protein Folding
Professional Background
2018-01-01OngoingAssociate ProfessorIndian Institute of Technology Roorkee
2012-01-011 year Research ScientistUniversity of Texas Medical Branch
2013-01-015 years Assistant ProfessorIndian Institute of Technology Roorkee
2009-01-012 years Postdoctoral Research AssociateRutgers University
2008-01-011 year Visiting FellowTata Institute of Fundamental Research
2007-01-01Visiting ScholarEuropean Molecular Biology Laboratory
2002-01-01Visiting Research ScholarTata Institute of Fundamental Research
Honors and Awards
Innovative Young Biotechnologist AwardDepartment of Biotechnology2013
NASI-Young Scientist Plantinum Jubilee AwardNational Academy of Sciences India2014
Young Scientist AwardIndian Science Congress Association2009
Best Oral PresentationIndian Biophysical Society2009
International Student FellowshipEuropean Science Foundation2007
Visiting Scholar FellowshipEuropean Molecular Biology organization2007
Best Oral PresentationRoyal Society of Chemistry, West India 2020
Best Poster AwardNuclear Magnetic Resonance Society, India2007
Gold Medal in M.ScAcharya Nagarjuna University2002
Educational Details
PhDMolecular Biophysics/ChemistryTata Institute of Fundamental Research, Mumbai2009
M.ScOrganic ChemistryAcharya Nagarjuna University2002
B.ScChemistry/Physics/MathsAcharya Nagarjuna University1999
Sponsored Research Projects
TopicFunding AgencyStart DatePeriod
Protein OligomerizationFIG-MHRD2013-017 years 7 months
Protein-Protein InteractionsSERB-DST2014-01Ongoing
Bio-molecular InteractionsIYBA-DBT2014-01Ongoing
  • Hindawi Publications: ISRN Structural Biology , Editorial Board Member
  • Academic Journals: Biotechnology and Molecular Biology Reviews , Editorial Board Member
  • Datasets International: Dataset papers in Biology -Biophysics , Editorial Board Member
  • Nuclear Magnetic Resonance Society , Life Member
  • Indian Biophysical Society , Life Member
  • Indian Science Congress Association , Life Member
Research Scholar Groups
Scholar NameInterest
Nidhi JoshiMechanisms of Protein Oligomerization
Krishnakant GangeleProtein folding and Biomolecular Interactions
PHDs Supervised
TopicScholar NameStatus of PHDRegistration Date
Delineating the Molecular Interactions of GRO ChemokinesKhushboo GulatiO2013-01
Biophysical Studies on Structural Transitions of T7 Bacteriophage EndolysinMeenakshi SharmaO2013-01
National International Collaboration
Biomolecular NMR Spectroscopy & Bio-nanotechnologyCenter for Biomedical Research, SGPGI Campus, Lucknow
Glycosaminoglycan mimeticsInstitute of Medical Physics and Biophysics, Leipzig University
Biomolecular interactions of organometallic CompoundsNorth easteren hill university
Books Authored



  1. Poluri KM* and Gulati G, “Protein Engineering Techniques: Gateways to Synthetic Protein Universe”, Springer Briefs in Applied Sciences and Technology - Forensic and Medical Bioinformatics, 2016.
  2. Mohan PMK*, "Dynamic Energy Landscape of Dynein Light Chain Protein", Lambert Academic Publishing "Monograph", ISBN: 978-384-848-154-5, 2012.

Book Chapters

  1. Mohan PMK*, "NMR Investigations on Ruggedness of Native State Energy Landscape in Folded Proteins", Intech open access publication "Protein Interaction/Book 2", ISBN 979-953-307-885-3., 2012.
  2. Nag N, Ramareddy T, Mamata K, Mohan PMK, Rao BJ, Mely Y, Duportail G and Krishnamoorthy G “Dynamics of DNA and DNA-protein complexes viewed through time-domain fluorescence”. Reviews in Fluorescence, Vol.3, 311- 340, 2006
Refereed Journal Papers
  1. Sharma M, Kumar D and Poluri KM* “Unraveling the differential structural stability and dynamics features of T7 endolysin partially folded conformations”, BBA Gen Subjects (In Press, 2018)
  2. Jaiswal N, Raikwal N, Pandey H, Agarwal N, Arora A, Poluri KM and Kumar D “Conformational heterogeneity of Histone-like DNA binding protein of Helicobacter pylori (Hup) elucidated by NMR” Mag. Res. Chem (In Press, 2018)
  3. Gulati K, Gangele K, Agarwal N, Jamsandekar M, Kumar D and  Poluri KM* “Molecular cloning and biophysical Characterization of CXCL3 chemokine”, Int. J. Biol. Macmol., 107, 575-584, 2018.
  4. Manikyam HK, Ramesh C, Poluri KM and Assad A “Microwave assisted subcritical water extraction of berberine hydrochloride from the roots of Berberis Aristata using harmony search algorithm”, J. of Herb. Med. Res 2:19, 2017.
  5. Gulati K, Jamsandekar M and Poluri KM* “Mechanistic insights into molecular evolution of species specific differential glycosaminoglycan binding surfaces in growth-related oncogene chemokines”, R Soc. Open Sci. 4(9):171059, 2017.
  6. Guleria A*, Meher MK, Prasad N, Poluri KM*, and Kumar D* “Physicochemical transformations of ZnO nanoparticles dispersed in peritoneal dialysis fluid: Insights into nano-bio interface interactions”, ACS J.Phys.Chem C. 121, 18598-18607, 2017.
  7. Gulati K#, Meher MK# and Poluri KM* “Glycosaminoglycan based resorbable polymer composites in tissue refurbishment”, Regen Med. 12(4):431-457, 2017. (#Equal Contribution)
  8. Arora N, Patel A, Sharma M, Mehtani J, Pruthi PA, , Pruthi V*, Poluri KM* “Insights into the enhanced lipid production characteristics of a fresh water microalga under high salinity conditions”, ACS Ind. Eng. Chem. Res. 56(25), 7413-21, 2017.
  9. Nair MS, D’Mello S, Pant R, Poluri KM “Binding of Resveratrol to the minor groove of DNA sequences with AATT and TTAA segments induces differential stability”, J Photochem Photobiol B. 170, 217-224, 2017.
  10. Punna Rao AB, Gulati K, Joshi N, Deb DK, Rambabu D, Kaminsky W, Poluri KM, Kollipara MR “Synthesis and biological studies of ruthenium, rhodium and iridium metal complexes with pyrazole-based ligands displaying unpredicted bonding modes”, Inorganica Chemica Acta 462, 223-234, 2017.
  11. Mehtani J#, Arora N#, Patel A, Jain P, Pruthi PA, Poluri KM, Pruthi V “Augmented lipid accumulation in mutants of ethyl methyl sulphonate oleaginous microalga for biodiesel production”, Bioresour Technol 242, 121-127, 2017.
  12. Arora N, Gulati K, Patel A, Pruthi PA, Poluri KM*, Pruthi V* “A hybrid approach integrating arsenic detoxification with biodiesel production using oleaginous microalgae”, Algal Research 24, 29-39, 2017.
  13. Kumar A, Gupta M, Mazumder A, Poluri KM, Rao VK, “ Use of box behnken design for development of high throughput quantitative proton nuclear magnetic resonance experiments for industrial applications”, ACS Ind. Eng. Chem. Res. 56, 2873-82, 2017.
  14. Punna Rao AB, Kalidasan M, Gangele K, Deb DK, Shepherd SL, Phillips RM, Poluri KM, Kollipara MR “Synthesis, structural and biological studies of some half-sandwich d6-metal complexes with pyrimidine-based ligands”, ChemistrySelect 2(6), 2065-76, 2017.
  15. Gulati K and Poluri KM* “An overview of computational and experimental methods for designing novel proteins”, Recent Pat Biotechnol. 10(3), 235-63, 2016.
  16. Gangele K and Poluri KM* “Imidazole derivatives differentially destabilize the low pH conformation of lysozyme through weak electrostatic interactions”, RSC Advances 6, 101395-403, 2016.
  17. Sawant KV, Poluri KM, Dutta AK, Sepuru KM, Troshkina A, Garofalo RP, Rajarathnam K “Chemokine CXCL1 mediated neutrophil recruitment: Role of glycosaminoglycan interactions”, Sci Rep 6:33123, 2016.
  18. Punna Rao AB, Uma A, Chiranjeevi T, Bethu MS, Yashwanth B, Venakteswara Rao J, Poluri KM, Kollipara MR “Synthesis, structural and in vitro functional characterization of arene ruthenium complexes with 1,3,5-tris(di-2-pyridylaminomethyl)benzene ligand”, Inorganica Chemica Acta 453, 284-291, 2016.
  19. Sharma M, Kumar D and Poluri KM* “Elucidating the pH-dependent structural transition of T7 bacteriophage endolysin”, ACS Biochemistry 55, 4614-25, 2016.
  20. Gulati K and Poluri KM* “Deciphering the in vitro homo and hetero oligomerization characteristics of CXCL1/CXCL2 chemokines”, RSC Advances 6, 28213-18, 2016.
  21. Gulati K and Poluri KM* “Mechanistic and therapeutic overview of glycosaminoglycans: the unsung heroes of biomolecular signaling”, Glycoconjugate Journal 33(1), 1-17, 2016.
  22. Brahma B, Patra MC, Karri S, Chopra M, Mishra P, De BC, Kumar S, Mahanty S, Thakur K, Poluri KM, Datta T and De S, “Diversity, antimicrobial action and structure-activity relationship of buffalo cathelicidins”  PlosOne, 10(12): e0144741, 2015.
  23. Gulati K and Poluri KM* “Chemoattractans, scaffolds and endogenous stem cells: Adorable partners of in situ tissue regeneration”, Austin J Biotechnol. Bioeng. 2(4) 1052, 2015 (Editorial)
  24. Joseph PR, Poluri KM, Sepuru KM, Rajarathnam K, “Characterizing protein-glycosaminoglycan interactions using solution NMR Spectroscopy”, Methods Mol  Biol . 1229, 325-33, 2015.
  25. Poluri KM* “Chemokines: The holy messengers of leukocyte trafficking”, Austin J Biotechnol. Bioeng. 1(3), 3, 2014. (Editorial)
  26. Sepuru KM, Poluri KM, and Rajarathnam K, “Solution structure of CXCL5 – A novel chemokine and adipokine implicated in inflammation and obesity”, PlosOne 9(4): e93228, 2014.
  27. Joseph PR, Poluri KM, Gangavarapu P, Rajagopalan L, Raghuwanshi S, Richardson RM, Garofalo RP, Rajarathnam K, “Proline substation of dimer interface b-strand residues as a strategy for the design of functional monomeric proteins”, BiophysJ., 105(6), 1491-501, 2013.
  28. Poluri KM, Joseph PR, Sawant KR and Rajarathnam K, “Molecular Basis for Glycosaminoglycan binding to Chemokine CXCL1 Dimer”. J Biol Chem., 278(22), 19980-19985, 2013.
  29. Chakraborty S, Mohan PMK, and Hosur RV, “Residual structure and dynamics in DMSO denatured DLC8”. Biochimie, 94(1):231-41, 2012
  30. Mohan PMK#, Chakraborty S# and Hosur RV, “Hierarchy of local structural and dynamics perturbations due to sub-denaturing urea in the native state ensemble of DLC8 dimer”. Biophys Chem., 153(1) 17-26, 2010. (#Equal Contribution)
  31. Mohan PMK, and Hosur RV, Structure-Function-Folding Relationships and Native Energy Landscape of Dynein Light Chain Protein: NMR Insights. J Biosci, 34(3):465-79, 2009.
  32. Mohan PMK, Chakraborty S and Hosur RV, “Thermodynamics of residue level unfolding in DLC8 dimer by temperature dependent native state hydrogen exchange”. J Biomol NMR, 44(1), 1-11, 2009
  33. Mohan PMK, Joshi MV and Hosur RV, “Hierarchy in guanidine unfolding of DLC8 dimer : Regulatory functional implications”. Biochimie, 91(3):401-7, 2009.
  34. Mohan PMK, Chakraborty S and Hosur RV, “Residue-wise Conformational Stability of DLC8 dimer from Native State Hydrogen Exchange”. Proteins, 75 (1), 40-52, 2009.
  35. Mohan PMK, and Hosur RV, “pH dependent unfolding characteristics of DLC8 dimer: residue level details from NMR”. BBA Proteins and Proteomics, 1784(11): 1795-1803, 2008.
  36. Mohan PMK and Hosur RV, “NMR characterization of structural and dynamics perturbations due to a single point mutation in Drosophila DLC8 dimer: Functional implications”. ACS Biochemistry, 47, 6251-6259, 2008.            
  37. Mohan PMK, Barve M, Chatterjee A, Ghosh-Roy A and Hosur RV, “NMR comparison of native energy landscapes of DLC8 dimer and monomer”. Biophysical Chemistry, 134, 10-19, 2008.
  38. Mohan PMK*, Mukherjee S, and Chary KVR, "Differential native state ruggedness of the two Ca2+-binding domains in a Ca2+ sensor protein". Proteins, 70, 1147-1153, 2008.
  39. Mohan PMK*, “Unfolding energetics and conformational stability of DLC8 monomer”. Biochimie, 89, 1409-1415, 2007.
  40. Mukherjee S, Mohan PMK, Kuchroo K, and Chary KVR, "Energetics of native energy landscape of a two-domain calcium sensor protein: distinct folding features of the two domains". ACS Biochemistry, 46, 9911-9919, 2007.
  41. Mohan PMK and Hosur RV, “NMR insights into dynamics regulated target binding of DLC8 dimer”. Biochem Biophys Res Commun, 355, 950-955, 2007.
  42. Mukherjee S, Mohan PMK, and Chary KVR, “Magnesium promotes structural integrity and conformational switching action of a calcium sensor protein”. ACS Biochemistry, 46, 3835-3845, 2007.
  43. Chatterjee A, Mohan PMK, Prabhu A­, Ghosh-Roy A and Hosur RV, “Equilibrium unfolding of DLC8 monomer by urea and guanidine hydrochloride: distinctive global and residue level features”. Biochimie, 89, 117-134, 2007.
  44. Mohan PMK, Barve M, Chatterjee A and Hosur RV, “pH driven conformational dynamics and dimer-to-monomer transition in DLC8”. Protein Sci., 15(2), 335-42, 2006.
  45. Bhavesh NS, Sinha R, Mohan PMK and Hosur RV, “NMR elucidation of early folding hierarchy in HIV-I protease”, J Biol Chem., 278(22), 19980-19985, 2003.
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